Open AccessApolipoproteins and cancer
Author(s) -
Ren Liwen,
Yi Jie,
Li Wan,
Zheng Xiangjin,
Liu Jinyi,
Wang Jinhua,
Du Guanhua
Publication year - 2019
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.2587
Subject(s) - cancer , disease , medicine , autophagy , oxidative stress , apolipoprotein b , bioinformatics , function (biology) , cancer research , oncology , biology , cholesterol , genetics , apoptosis
Abstract The role of apolipoproteins in cardiovascular disease has been well investigated, but their participation in cancer has only been explored in a few published studies which showed a close link with certain kinds of cancer. In this review, we focused on the function of different kinds of apolipoproteins in cancers, autophagy, oxidative stress, and drug resistance. The potential application of apolipoproteins as biomarkers for cancer diagnosis and prognosis was highlighted, together with an investigation of their potential as drug targets for cancer treatment. Many important roles of apolipoproteins and their mechanisms in cancers were reviewed in detail and future perspectives of apolipoprotein research were discussed.