Open AccessClinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms
Author(s) -
Zhang Yu,
Shang Liang,
Zhang PanPan,
Chen LuoHai,
Wang Wei,
Fang Cheng,
Qiu Meng,
Feng XingYu,
Zhou Lin,
Zhang Meng,
Tan HuangYing,
Qiu XuDong,
Wang Hao,
Lin Rong,
Zhang Qin,
Zeng YuJie,
Jin KaiZhou,
Yu XianJun,
Shen Lin,
Chen MinHu,
Li Jie,
Li LePing,
Chen Jie
Publication year - 2019
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.2370
Subject(s) - medicine , cohort , hindgut , neuroendocrine tumors , oncology , cancer , epidemiology , cohort study , stage (stratigraphy) , midgut , biology , paleontology , botany , larva
Purpose This study aimed to investigate the characteristics of colonic neuroendocrine neoplasms (NENs) and to validate the prognostic value of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems. Methods A total of 167 and 1248 patients with colonic NENs from 12 medical centers across China and from the Surveillance, Epidemiology, and End Results (SEER) cancer registry in the United States, respectively, were reviewed. Patients were staged according to the ENETS and AJCC 8th staging systems. Results Clinicopathological features of colonic NENs in the Chinese cohort and SEER cohort were significantly distinct. In both the Chinese cohort and the SEER cohort, colonic neuroendocrine carcinoma (NEC) and mixed adeno‐neuroendocrine carcinoma (MANEC) were more frequent in the midgut than in the hindgut. Tumors originating from the midgut tended to be larger and at a more advanced stage than those from the hindgut. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC. Conclusions Our study revealed that tumors originating from the midgut and the hindgut shared different clinicopathological features. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.