Open AccessThe Ca 2+ ‐activated Cl − channel, ANO1 (TMEM16A), is a double‐edged sword in cell proliferation and tumorigenesis
Author(s) -
Qu Zhiqiang,
Yao Weicheng,
Yao Ruyong,
Liu Xiangping,
Yu Kuai,
Hartzell Criss
Publication year - 2014
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.232
Subject(s) - carcinogenesis , cancer research , cancer , biology , cell growth , biomarker , malignant transformation , microbiology and biotechnology , function (biology) , genetics
Since anoctamin 1 ANO 1 ( TMEM 16A) was found to be a molecular component of Ca 2+ ‐activated Cl − channels, its role in tumorigenesis has gained attention at a fast pace. ANO 1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO 1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO 1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO 1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO 1 as a target for cancer treatment.