Open AccessDecreased decorin expression in the tumor microenvironment
Author(s) -
Bozoky Benedek,
Savchenko Andrii,
Guven Hayrettin,
Ponten Fredrik,
Klein George,
Szekely Laszlo
Publication year - 2014
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.231
Subject(s) - decorin , proteoglycan , stroma , tumor microenvironment , biglycan , biology , connective tissue , microbiology and biotechnology , immunohistochemistry , extracellular matrix , chemistry , cancer research , immunology , tumor cells , genetics
Decorin is a small leucine‐rich proteoglycan, synthesized and deposited by fibroblasts in the stroma where it binds to collagen I. It sequesters several growth factors and antagonizes numerous members of the receptor tyrosine kinase family. In experimental murine systems, it acted as a potent tumor suppressor. Examining the Human Protein Atlas online database of immunostained tissue samples we have surveyed decorin expression in silico in several different tumor types, comparing them with corresponding normal tissues. We found that decorin is abundantly secreted and deposited in normal connective tissue but its expression is consistently decreased in the tumor microenvironment. We developed a software to quantitate the difference in expression. The presence of two closely related proteoglycans in the newly formed tumor stroma indicated that the decreased decorin expression was not caused by the delay in proteoglycan deposition in the newly formed connective tissue surrounding the tumor.