Open AccessThe prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5‐azacytidine: Results from the Hellenic 5‐azacytidine registry
Author(s) -
Diamantopoulos Panagiotis,
Koumbi Dafni,
Kotsianidis Ioannis,
Pappa Vasiliki,
Symeonidis Argiris,
Galanopoulos Athanasios,
Zikos Panagiotis,
Papadaki Helen A.,
Panayiotidis Panayiotis,
Dimou Maria,
Hatzimichael Eleftheria,
Vassilopoulos George,
Delimpasis Susan,
Mparmparousi Despoina,
Papageorgiou Sotirios,
Variami Eleni,
Kyrtsonis MarieChristine,
Megalakaki Aekaterini,
Kotsopoulou Maria,
Repousis Panagiotis,
Adamopoulos Ioannis,
Kontopidou Flora,
Christoulas Dimitrios,
Kourakli Alexandra,
Tsokanas Dimitrios,
Konstantinos Papoutselis Menelaos,
Kyriakakis Georgios,
Viniou NoraAthina
Publication year - 2019
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.2090
Subject(s) - isochromosome , karyotype , abnormality , chromosome abnormality , chromosomal translocation , international prognostic scoring system , chromosome , medicine , clinical significance , cytogenetics , context (archaeology) , myelodysplastic syndromes , biology , pathology , oncology , genetics , bone marrow , gene , paleontology , psychiatry
In patients with myelodysplastic syndrome (MDS), the prognostic significance of chromosome 17 abnormalities has not yet been fully elucidated, except for isochromosome 17q that has been characterized as an intermediate risk abnormality in the Revised International Prognostic Scoring System (IPSS‐R). To further characterize the prognostic significance of chromosome 17 abnormalities we analyzed the hematologic and prognostic characteristics of 548 adult patients with MDS treated with 5‐azacytidine through the Hellenic 5‐azacytidine registry and found 32 patients with a chromosome 17 abnormality (6 with i[17q], 15 with ‐17, 3 with add[17p] and the rest with other rarer abnormalities, mostly translocations). The presence of a chromosome 17 abnormality was correlated with poor prognostic features (high IPSS, IPSS‐R, and WPSS scores) and a low overall survival rate (15.7 vs 36.4 months for patients without chromosome 17 abnormalities, Kaplan–Meier, Log Rank P < 0.00001), but these results were confounded by the fact that most (92.3%) of the cases with a chromosome 17 abnormality (with the exception of i(17q) that was found in all cases as an isolated abnormality) were found in the context of a complex karyotype. Nevertheless, one should not ignore the contribution of chromosome 17 abnormalities to the prognostic significance of a complex karyotype since 33.8% of complex karyotypes encompassed a chromosome 17 abnormality.