Human cancer, the naked mole rat and faunal turnovers | Zendy

Bredberg Anders | Zendy; Schmitz Birger | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Human cancer, the naked mole rat and faunal turnovers

Author(s) -

Bredberg Anders,

Schmitz Birger

Publication year - 2019

Publication title -

cancer medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.403

H-Index - 53

ISSN - 2045-7634

DOI - 10.1002/cam4.2011

Subject(s) - cancer , mole , offspring , biology , resistance (ecology) , evolutionary biology , zoology , ecology , demography , genetics , biochemistry , sociology , pregnancy

We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade‐off between offspring variability and cancer resistance, and thus favored cancer‐prone individuals. We turn the attention to a factor setting the highly cancer‐resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30‐50 million years ago. Research focusing on DNA stability mechanisms in ‘living fossil’ animals may help us find tools for cancer prevention and treatment.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research