Open AccessSerum folate receptor α (sFR) in ovarian cancer diagnosis and surveillance
Author(s) -
Farran Batoul,
Albayrak Samet,
Abrams Judith,
Tainsky Michael A.,
Levin Nancy K.,
Morris Robert,
Matherly Larry H.,
Ratnam Manohar,
Winer Ira
Publication year - 2019
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1944
Subject(s) - medicine , ovarian cancer , novelty , folate receptor , cohort , cancer , prospective cohort study , oncology , receptor , gynecology , cancer cell , philosophy , theology
Abstract Novelty and Impact Statement: Our findings suggest that soluble folate receptor (sFR) could be used in both the initial diagnosis and surveillance of patients with ovarian cancer. Our cohort constitutes one of the largest comparison groups for sFR analyzed so far. We have defined the background level of sFR using healthy volunteers. This is also the first study to prospectively follow patients in the surveillance setting to concurrently identify differential changes in tumor markers CA‐125 and sFR.