Open AccessRisk of newly detected infections and cervical abnormalities in adult women seropositive or seronegative for naturally acquired HPV‐16/18 antibodies
Author(s) -
Rosillon Dominique,
Baril Laurence,
Del RosarioRaymundo Maria Rowena,
Wheeler Cosette Marie,
Skinner Susan Rachel,
Garland Suzanne Marie,
Salmeron Jorge,
LazcanoPonce Eduardo,
Vallejos Carlos Santiago,
Stoney Tanya,
ter Harmsel Bram,
Lim Timothy Yong Kuei,
Quek Swee Chong,
Minkina Galina,
McNeil Shelly Ann,
Bouchard Celine,
Fong Kah Leng,
Money Deborah,
Ilancheran Arunachalam,
Savicheva Alevtina,
Cruickshank Margaret,
Chatterjee Archana,
Fiander Alison,
Martens Mark,
Bozonnat Marie Cecile,
Struyf Frank,
Dubin Gary,
Castellsagué Xavier
Publication year - 2019
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1879
Subject(s) - serostatus , medicine , hazard ratio , antibody , immunogenicity , hpv infection , immunology , gastroenterology , cervical cancer , virus , confidence interval , cancer , viral load
Background Infections with human papillomavirus (HPV) types 16 and 18 account for ~70% of invasive cervical cancers but the degree of protection from naturally acquired anti‐HPV antibodies is uncertain. We examined the risk of HPV infections as defined by HPV DNA detection and cervical abnormalities among women >25 years in the Human Papilloma VIrus Vaccine Immunogenicity ANd Efficacy trial's (VIVIANE, NCT00294047) control arm. Methods Serum anti‐HPV‐16/18 antibodies were determined at baseline and every 12 months in baseline DNA‐negative women (N = 2687 for HPV‐16 and 2705 for HPV‐18) by enzyme‐linked immunosorbent assay (ELISA) from blood samples. HPV infections were identified by polymerase chain reaction (PCR) every 6‐months, and cervical abnormalities were confirmed by cytology every 12 months. Data were collected over a 7‐year period. The association between the risk of type‐specific infection and cervical abnormalities and serostatus was assessed using Cox proportional hazard models. Results Risk of newly detected HPV‐16‐associated 6‐month persistent infections (PI) (hazard ratio [HR] = 0.56 [95%CI:0.32; 0.99]) and atypical squamous cells of undetermined significance (ASC‐US+) (HR = 0.28 [0.12; 0.67]) were significantly lower in baseline seropositive vs baseline seronegative women. HPV‐16‐associated incident infections (HR = 0.81 [0.56; 1.16]) and 12‐month PI (HR = 0.53 [0.24; 1.16]) showed the same trend. A similar trend of lower risk was observed in HPV‐18‐seropositive vs ‐seronegative women (HR = 0.95 [0.59; 1.51] for IIs, HR = 0.43 [0.16; 1.13] for 6‐month PIs, HR = 0.31 [0.07; 1.36] for 12‐month PIs, and HR = 0.61 [0.23; 1.61] for ASC‐US+). Conclusions Naturally acquired anti‐HPV‐16 antibodies were associated with a decreased risk of subsequent infection and cervical abnormalities in women >25 years. This possible protection was lower than that previously reported in 15‐ to 25‐year‐old women.