Open AccessAssociation between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer
Author(s) -
Huang Naisi,
Chen Xingxing,
Wei Wenjun,
Mo Miao,
Chen Jiaying,
Ma Ben,
Yang Shuwen,
Xu Weibo,
Wu Jiong,
Ji Qinghai,
Guo Xiaomao,
Liu Guangyu,
Shao Zhimin,
Wang Yu
Publication year - 2018
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1856
Subject(s) - medicine , breast cancer , odds ratio , malignancy , incidence (geometry) , thyroid cancer , risk factor , cancer , retrospective cohort study , standardized mortality ratio , oncology , papillary thyroid cancer , gynecology , gastroenterology , physics , optics
Background Thyroid cancer (TC) is one of the most commonly seen secondary malignancy in breast cancer (BC) survivors. Materials and methods A retrospective study was conducted in BC patients in our center from 1999 to 2013. Patients were divided into BC‐TC group and BC‐alone group. Results In total, 13 978 BC patients were identified, among whom 247 (1.8%) had TC. The standardized incidence ratio (SIR) of TC was 4.48 compared with Chinese females, and up to 98.0% of cases were thyroid papillary carcinomas. A family history of malignancy was the only independent risk factor (odds ratio = 1.457, P = 0.025) for development of TC in patients with BC. We also identified inferior survival in patients with synchronous versus metachronous BC‐TC ( P = 0.016). Synchronous BC‐TC (risk ratio = 5.597, P = 0.018) was an independent prognostic factor for inferior RFS. Conclusions We observed high co‐occurrence of TC in patients with BC. There might be different mechanisms behind synchronous and metachronous BC‐TC.