Open AccessRenal cell carcinoma risk associated with lower intake of micronutrients
Author(s) -
Bock Cathryn H.,
Ruterbusch Julie J.,
Holowatyj Andrea.,
Steck Susan E.,
Van Dyke Alison L.,
Ho Won Jin,
Cote Michele L.,
Hofmann Jonathan N.,
Davis Faith,
Graubard Barry I.,
Schwartz Kendra L.,
Purdue Mark P.
Publication year - 2018
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1639
Subject(s) - micronutrient , medicine , renal cell carcinoma , physiology , vitamin e , population , quartile , vitamin , odds ratio , kidney cancer , lower risk , vitamin c , environmental health , biology , antioxidant , pathology , confidence interval , biochemistry
Kidney cancer incidence in African Americans ( AA ) is higher than among European Americans ( EA ); reasons for this disparity are not fully known. Dietary micronutrients may have a protective effect on renal cell carcinoma ( RCC ) development by inhibiting oxidative DNA damage and tumor growth. We evaluated whether any micronutrient associations differed by race in the US Kidney Cancer Study. 1142 EA and AA RCC cases and 1154 frequency‐matched controls were enrolled in a population‐based case‐control study between 2002 and 2007. Dietary micronutrient intake was derived from an interviewer‐administered diet history questionnaire. RCC risk associated with micronutrient intake was estimated using adjusted odds ratios from logistic regression comparing lower to highest quartiles of intake and sample weighting. Inverse associations with RCC risk were observed for α‐carotene, β‐carotene, lutein zeaxanthin, lycopene, vitamin A, folate, thiamin, vitamin C, α‐tocopherol, β‐tocopherol, γ‐tocopherol, and selenium. A trend for β‐cryptoxanthin was suggested among EA but not AA or the total sample ( P‐ interaction = .04). Otherwise, findings did not differ by race, gender, age, or smoking status. The increase in RCC risk associated with lower micronutrient intake is similar within AA and EA populations. A diet rich in sources of micronutrients found in fruits, vegetables, and nuts may help to reduce the overall risk of RCC .