Open AccessVacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
Author(s) -
Whitton Bradleigh,
Okamoto Haruko,
Packham Graham,
Crabb Simon J.
Publication year - 2018
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1594
Subject(s) - mediator , atpase , intracellular , v atpase , metastasis , cancer cell , microbiology and biotechnology , cancer , transporter , protein subunit , biology , chemistry , enzyme , biochemistry , gene , genetics
Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H + ‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes. This review focuses on emerging evidence for the roles for V‐ATPase in cancer. This includes how V‐ATPase dysregulation contributes to cancer growth, metastasis, invasion and proliferation, and the potential link between V‐ATPase and the development of drug resistance.