Open AccessPredictive impact of the inflammation‐based indices in colorectal cancer patients with adjuvant chemotherapy
Author(s) -
Tao Yong,
Ding Lei,
Yang Guan Gen,
Qiu Jian Ming,
Wang Dong,
Wang Hongtao,
Fu Chao
Publication year - 2018
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1542
Subject(s) - medicine , colorectal cancer , proportional hazards model , oncology , receiver operating characteristic , multivariate analysis , univariate , chemotherapy , neutrophil to lymphocyte ratio , univariate analysis , biomarker , cancer , multivariate statistics , adjuvant chemotherapy , survival analysis , overall survival , breast cancer , biochemistry , statistics , mathematics , chemistry
Increasing evidences reported that cancer‐triggered inflammation was associated with survival prognosis from colorectal cancer ( CRC ). However, the comprehensive effects of inflammatory‐based co NLR ‐ PLR that combines neutrophil‐to‐lymphocyte ratio ( NLR ) and platelet‐to‐lymphocyte ratio ( PLR ) rarely remain to be determined during chemotherapy. We retrospectively analyzed clinical data and baseline laboratory parameters from 153 colorectal cancer patients who underwent palliative adjuvant chemotherapy between January 2009 to January 2012. Receiver operating characteristic ( ROC ) curves and linear regression analyzed the predictive ability of NLR , and PLR for calculating the score of co NLR ‐ PLR . Overall survival ( OS ) and recurrence‐free survival ( RFS ) rates were estimated using the Kaplan‐Meier method and analyzed by the Cox proportional hazards model in univariate and multivariate analysis. The optimal cut‐off value of NLR and PLR was 2.24 and 186 by the ROC analysis. Kaplan‐Meier method showed that patients with high co NLR ‐ PLR score was associated with poorer OS and RFS (all P < .05). In univariate and multivariate analysis, it obtained that the co NLR ‐ PLR severed as a strong independent prognostic factor for OS and RFS (all P < .05). These results highlight that co NLR ‐ PLR index severed as a strong predictor of prognosis biomarker in CRC patients receiving adjuvant chemotherapy. Furthermore, its assessment could contribute to accurately predicting prognosis after chemotherapy in clinical practice.