Open AccessLong non‐coding RNA GAS 5 is induced by interferons and plays an antitumor role in esophageal squamous cell carcinoma
Author(s) -
Huang Jianbing,
Li Yuan,
Lu Zhiliang,
Che Yun,
Sun Shouguo,
Mao Shuangshuang,
Lei Yuanyuan,
Zang Ruochuan,
Li Ning,
Sun Nan,
He Jie
Publication year - 2018
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1524
Subject(s) - esophageal squamous cell carcinoma , cancer research , cell , rna , long non coding rna , basal cell , coding (social sciences) , medicine , carcinoma , chemistry , biology , oncology , biochemistry , gene , statistics , mathematics
The long non‐coding RNA GAS 5 has been reported as a tumor suppressor in many cancers. However, its functions and mechanisms remain largely unknown in esophageal squamous cell carcinoma ( ESCC ). In this study, we found that GAS 5 was over‐expressed in ESCC tissue compared with that in normal esophageal tissue in a public database. Functional studies showed that GAS 5 could inhibit ESCC cell proliferation, migration and invasion in vitro. Further analysis revealed that GAS 5 was regulated by interferon ( IFN ) responses via the JAK ‐ STAT pathway. Moreover, as an IFN ‐stimulated gene ( ISG ), GAS 5 was a positive regulator of IFN responses. The feedback loop between GAS 5 and the IFN signaling pathway plays an important antitumor role in ESCC , thus providing novel potential therapeutic targets.