Open AccessPrognostic significance of combined pretreatment lymphocyte counts and body mass index in patients with head and neck cancer treated with radiation therapy
Author(s) -
Wu YaoYu,
Chang KaiPing,
Lin ChienYu,
Pai PingChing,
Wang HungMing,
Hsu ChengLung,
Liao ChunTa,
Yen TzuChen,
Fang TuanJen,
Huang ShiangFu,
Kang ChungJan,
Fang KuHao,
Lin WanNi,
Wang YuChien,
Hsin LiJen,
Tsang NganMing
Publication year - 2018
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1489
Subject(s) - medicine , head and neck cancer , body mass index , distant metastasis , radiation therapy , stage (stratigraphy) , nasopharyngeal cancer , oncology , cancer , metastasis , head and neck , overall survival , gastroenterology , surgery , nasopharyngeal carcinoma , paleontology , biology
We aimed to investigate the prognostic significance of combined pretreatment lymphocyte counts ( LC s) and body mass index ( BMI ) in patients with head and neck cancer ( HNC ) treated with radiation therapy ( RT ). Nine hundred and twelve patients with HNC who were treated with RT were retrospectively reviewed. Survival was analyzed by stratifying the patients according to pretreatment LC s and BMI . Patients with low pretreatment LC s and BMI were characterized by a more advanced T stage, fewer nasopharyngeal subsites, less smoking and drinking, and fewer comorbidities. Patients with low pretreatment LC s and BMI had a significantly poorer overall and distant metastasis‐free survival than those with high pretreatment LC s and BMI . No significant differences were observed in terms of local or regional recurrence‐free survival. Combined pretreatment LC s and BMI may be more effective at predicting overall and distant metastasis‐free survival in patients with HNC treated with RT .