Open AccessProspective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial
Author(s) -
Italiano Antoine,
Touati Nathan,
Litière Saskia,
Collin Françoise,
Pourquier Philippe,
Gronchi Alessandro
Publication year - 2018
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1403
Subject(s) - trabectedin , predictive value , oncology , medicine , sarcoma , soft tissue sarcoma , pathology
We describe the predictive value of BRCA1 gene status on trabectedin efficacy and found no correlation despite the mechanisms of action of this drug that rely on DNA repair systems.
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