Open AccessThe prognostic value of CYP 2C subfamily genes in hepatocellular carcinoma
Author(s) -
Wang Xiangkun,
Yu Tingdong,
Liao Xiwen,
Yang Chengkun,
Han Chuangye,
Zhu Guangzhi,
Huang Ketuan,
Yu Long,
Qin Wei,
Su Hao,
Liu Xiaoguang,
Peng Tao
Publication year - 2018
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1299
Subject(s) - hepatocellular carcinoma , cytochrome p450 , biology , hazard ratio , subfamily , medicine , proportional hazards model , oncology , cyp2c8 , gene , cancer research , endocrinology , genetics , confidence interval , cyp3a4 , metabolism
Cytochrome P2C ( CYP 2C) subfamily members ( CYP 2C8 , CYP 2C9 , CYP 2C18 , and CYP 2C19 ) are known to participate in clinical drug metabolism. However, the association between CYP 2C subfamily members and hepatocellular carcinoma ( HCC ) remains unclear. This study investigated the prognostic value of CYP 2C subfamily gene expression levels with HCC prognosis. Data of 360 HCC patients in The Cancer Genome Atlas database and 231 in the Gene Expression Omnibus database were analyzed. Kaplan–Meier analysis and a Cox regression model were used to ascertain overall survival and recurrence‐free survival, and to calculate median survival time using hazard ratios ( HR ) and 95% confidence intervals ( CI ). In TCGA database, low expression of CYP 2C8 , CYP 2C9 , and CYP 2C19 in tumor tissue was associated with a short median survival time (all crude P = 0.001, adjusted P = 0.004, P = 0.047, and P = 0.020, respectively). In TCGA database, joint effects analysis of the combinations of CYP 2C8 and CYP 2C9 , CYP 2C8 and CYP 2C19 , and CYP 2C9 and CYP 2C19 revealed that high expression of two genes (group 4; group IV , group d ) was associated with a reduced risk of death as compared to low expression (group 1, group I, and group a ) (adjusted P = 0.005, P = 0.013, and P = 0.016, respectively). In TCGA database, joint effects analysis of CYP 2C8 , CYP 2C9 , and CYP 2C19 showed that the risk of death from HCC was lower for groups C and D than for group A (adjusted P = 0.012 and P = 0.008, respectively). CYP 2C8 , CYP 2C9 , and CYP 2C19 gene expression levels are potential prognostic markers of HCC following hepatectomy.