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Prognostic significance of postoperative pneumonia after curative resection for patients with gastric cancer
Author(s) -
Tu RuHong,
Lin JianXian,
Li Ping,
Xie JianWei,
Wang JiaBin,
Lu Jun,
Chen QiYue,
Cao Longlong,
Lin Mi,
Zheng ChaoHui,
Huang ChangMing
Publication year - 2017
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1163
Subject(s) - medicine , gastrectomy , pneumonia , proportional hazards model , stage (stratigraphy) , cancer , risk factor , incidence (geometry) , surgery , complication , gastroenterology , chemotherapy , survival analysis , retrospective cohort study , paleontology , physics , optics , biology
Few studies have been designed to investigate the incidence of postoperative pneumonia after radical gastrectomy and its effect on prognosis of these patients. Incidences of postoperative pneumonia after radical gastrectomy in our department between January 1996 and December 2014 were summarized. Their effects on prognosis were retrospectively analyzed using survival curves and Cox regression. A total of 5237 patients were included in this study, 767 (14.4%) of them had complications, including 383 cases of postoperative pneumonia (7.2%). The 5‐year overall and disease‐specific survival of patients with postoperative pneumonia were both lower than those without this complication ( P  < 0.001). Stratified analysis demonstrated that this difference existed in all Stage I, II , and III patients (log‐rank, P  < 0.05). Multivariate analysis revealed that age, neoadjuvant chemotherapy, tumor size, tumor stage, and postoperative pneumonia were independent risk factors for disease‐specific survival. Postoperative pneumonia after radical gastrectomy is an independent risk factor for prognosis of gastric cancer patients, especially in stage III .

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