Open AccessEndocrine toxicity of immune checkpoint inhibitors: essential crosstalk between endocrinologists and oncologists
Author(s) -
Illouz Frédéric,
Briet Claire,
Cloix Lucie,
Le Corre Yannick,
Baize Nathalie,
Urban Thierry,
Martin Ludovic,
Rodien Patrice
Publication year - 2017
Publication title -
cancer medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 53
ISSN - 2045-7634
DOI - 10.1002/cam4.1145
Subject(s) - medicine , ipilimumab , adverse effect , toxicity , immunotherapy , endocrine system , immune system , immunology , oncology , hormone
Two types of immune checkpoint inhibitors, both antibodies that target cytotoxic T‐lymphocyte antigen‐4 and those that target programmed cell death‐protein 1, have been approved for use in melanoma, non‐small‐cell lung cancer, and renal cell carcinoma as first‐line or second‐line therapy. Their adverse events are primarily regarded as immune‐related adverse events. We felt it was important to pinpoint and discuss certain preconceptions or misconceptions regarding thyroid dysfunction, hypophysitis, and diabetes induced by immune checkpoint inhibitors. We have identified areas of uncertainty and unmet requirements, including essential interaction between endocrinologists and oncologists. Five issues have been identified for discussion: (1) diagnosis of endocrine toxicity, (2) assessment of toxicity severity, (3) treatment of toxicity, (4) withdrawal or continuation of immunotherapy, (5) preventive action.