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Cohesion of Cortical Language Networks During Word Processing Is Predicted by a Common Polymorphism in the SETBP1 Gene
Author(s) -
Rakhlin Natalia,
Landi Nicole,
Lee Maria,
Magnuson James S.,
Naumova Oxana Yu.,
Ovchinnikova Irina V.,
Grigorenko Elena L.
Publication year - 2020
Publication title -
new directions for child and adolescent development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.628
H-Index - 59
eISSN - 1534-8687
pISSN - 1520-3247
DOI - 10.1002/cad.20331
Subject(s) - endophenotype , psychology , population , single nucleotide polymorphism , neuroscience , genome wide association study , genetics , gene , biology , developmental psychology , cognition , genotype , medicine , environmental health
The etiological mechanisms of the genetic underpinnings of developmental language disorder (DLD) are unknown, in part due to the behavioral heterogeneity of the disorder's manifestations. In this study, we explored an association between the SETBP1 gene (18q21.1), revealed in a genome‐wide association study of DLD in a geographically isolated population, and brain network‐based endophenotypes of functional intracortical coherence between major language‐related brain areas. We analyzed electroencephalogram (EEG) data from thirty‐nine children (twenty‐three with, sixteen without DLD) aged 7.17–15.83 years acquired during an auditory picture–word matching paradigm. Variation at a single nucleotide polymorphism in the intronic region of the SETBP1 gene, rs8085464, explained 19% of the variance in intracortical network cohesion ( p = .00478). This suggests that the development of these brain networks might be partially associated with the variation in SETBP1 .