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Cytoarchitecture of diabetic myopathy during the pathogenesis of the disease: Fast versus slow muscle
Author(s) -
Klueber Kathleen M.,
Porta David J.
Publication year - 1994
Publication title -
clinical anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 71
eISSN - 1098-2353
pISSN - 0897-3806
DOI - 10.1002/ca.980070606
Subject(s) - pathogenesis , medicine , myopathy , denervation , reinnervation , amyotrophy , weakness , peripheral neuropathy , soleus muscle , diabetes mellitus , muscle weakness , diabetic neuropathy , anatomy , endocrinology , pathology , skeletal muscle , atrophy
Diabetic patients exhibit varying degrees of peripheral neuropathy. One of the sequelae of the neuropathy is muscle weakness in the lower limbs, described either as diabetic amyotrophy if the weakness affects the proximal musculature, or motor neuropathy if it affects the distal musculature. The weakness is thought to be related to metabolic disturbances of the disease and changes in the peripheral nerve. In animal models of diabetes, degeneration of myofibers and imyoneural junctions has been noted in both fast (extensor digitorum longus, EDL), and slow (soleus, SOL) muscles. However, observations of changes in skeletal muscle during the pathogenesis of the disease have not been made in either human or animal models of diabetes. It is the purpose of this study to compare the time course in the pathogenesis of diabetic myopathy in these two different types of muscles. Soleus and EDL muscles from 6, 14, and 24+‐week‐old C57BL/KsJ‐ db / db and db/ + female mice (N = 12/group) were fixed in situ, processed using standard electron microscopic procedures, and analyzed under the electron microscope. Although both muscles exhibited signs of degeneration, disruption of the mitochondria, and excessive lipid stores, the initial onset and the extent of the myopathy were delayed in soleus. In addition, fewer myofibers in the soleus muscle exhibited signs of denervation and reinnervation. Therefore, diabetic myopathy is progressive during the pathogenesis of the disease but SOL appears to be more resistant to progression of the disease. © 1994 Wiley‐Liss, Inc.