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Modulation of bone growth and remodeling by the sympathetic nervous system: Review of experimental and clinical studies
Author(s) -
Herskovits Mark S.,
Sandhu Harinder S.,
Singh Inder J.
Publication year - 1991
Publication title -
clinical anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 71
eISSN - 1098-2353
pISSN - 0897-3806
DOI - 10.1002/ca.980040208
Subject(s) - medicine , sympathetic nervous system , sympathectomy , bone remodeling , autonomic nervous system , dystrophy , reflex , central nervous system , nervous system , bone resorption , endocrinology , pathology , heart rate , psychiatry , blood pressure
The purpose of this paper is to review the interactions of the skeletal and sympathetic nervous systems during normal growth and function as well as in pathology. Clinical and experimental studies have shown that the sympathetic nervous system may play a role in the severity of arthritis and in bone lesions evident in reflex sympathetic dystrophy. In experimental animal studies, bone deposition and mineralization significantly decreased, while bone resorption was significantly increased after sympathectomy. The findings form a basis for understanding the effects of autonomic dysfunction on the skeleton and indicate areas in which further research may have implications for the treatment of skeletal disorders.