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Morphometric changes in perfused microvasculature in experimental focal cerebral ischemia in primates
Author(s) -
Theodore Deepa R.,
MeierRuge W.,
Abraham Jacob
Publication year - 1991
Publication title -
clinical anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 71
eISSN - 1098-2353
pISSN - 0897-3806
DOI - 10.1002/ca.980040203
Subject(s) - medicine , perfusion , middle cerebral artery , anatomy , india ink , ischemia , cortex (anatomy) , caudate nucleus , microcirculation , cerebral cortex , occlusion , insular cortex , pathology , cardiology , neuroscience , biology , psychiatry
A significant reduction in perfused microvasculature in right caudate nucleus and right insular cortex was demonstrated in 22 monkeys at 0.5, 4, 12, 24, and 48 hours and 2 weeks following transorbital occlusion of the right middle cerebral artery (RMCA). The microvasculature was visualized by an india ink perfusion method and subjected to morphometric analysis with a Leitz ASBA image analysis system. The reduction in number, length, and changes in diameter of the microvessels visualized with india ink are discussed.