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Total microvasculature in insula and caudate nucleus following occlusion of middle cerebral artery in monkeys
Author(s) -
Theodore Deepa R.,
MeierRuge W.,
Abraham Jacob
Publication year - 1991
Publication title -
clinical anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 71
eISSN - 1098-2353
pISSN - 0897-3806
DOI - 10.1002/ca.980040202
Subject(s) - medicine , caudate nucleus , insula , middle cerebral artery , insular cortex , occlusion , anatomy , cerebral cortex , cortex (anatomy) , neuroscience , biology , ischemia , psychiatry
Total microvasculature of insula and caudate nucleus of 36 monkeys following right middle cerebral artery occlusion was subjected to a sequential morphometric analysis with Leitz ASBA image analysis system. Total microvasculature comprising perfused functional and nonperfused reserve parts was visualized by staining alkaline phosphatase activity in the vessel wall. Number, length, and volume of visualized microvasculature increased at 0.5, 4, and 12 hours in both areas and in addition to at 24 hours in the insular cortex. Diameter and area of the microvessels were increased at 4 hours in caudate and at 0.5, 4, and 12 hours in the insular cortex followed by a decrease at 48 hours and 2 weeks in both. The intermicrovascular distance was significantly increased at 48 hours and 2 weeks in caudate. In insula it had decreased significantly at four, 12 and 24 hours and 2 weeks and increased at 48 hours following occlusion.