Premium
Human embryonic stem cells: Distinct molecular personalities and applications in regenerative medicine
Author(s) -
Dupont Graham,
Yilmaz Emre,
Loukas Marios,
Macchi Veronica,
De Caro Raffaele,
Tubbs R. Shane
Publication year - 2019
Publication title -
clinical anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 71
eISSN - 1098-2353
pISSN - 0897-3806
DOI - 10.1002/ca.23318
Subject(s) - embryonic stem cell , regenerative medicine , stem cell , medicine , induced pluripotent stem cell , blastocyst , stem cell biology , bioinformatics , neuroscience , pathology , microbiology and biotechnology , biology , genetics , embryo , embryogenesis , reproductive technology , gene
The field of stem cell biology is exciting because it provides researchers and clinicians with seemingly unlimited applications for treating many human diseases. Stem cells are a renewable source of pluripotent cells that can differentiate into nearly all human cell types. In this article we focus particularly on human embryonic stem (hES) cells, derived from the inner cell mass of the blastocyst and cultured for expansion while remaining undifferentiated, to explore their unique molecular personalities and clinical applications. The aim of this literature review is to reflect the interest in hES cells and to provide a resource for researchers and clinicians interested in the molecular characteristics of such cells. Clin. Anat. 32:354–360, 2019. © 2018 The Authors. Clinical Anatomy published by Wiley Periodicals, Inc. on behalf of American Association of Clinical Anatomists.