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Differences in and correlations between cognitive abilities and brain volumes in healthy control, mild cognitive impairment, and Alzheimer disease groups
Author(s) -
Chung SoonCheol,
Choi MiHyun,
Kim HyungSik,
Lee JungChul,
Park SungJun,
Jeong UlHo,
Baek JiHye,
Gim SeonYoung,
Choi Young Chil,
Lee BeobYi,
Lim DaeWoon,
Kim Boseong
Publication year - 2016
Publication title -
clinical anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 71
eISSN - 1098-2353
pISSN - 0897-3806
DOI - 10.1002/ca.22684
Subject(s) - medicine , cognitive impairment , audiology , cognition , white matter , boston naming test , alzheimer's disease , correlation , cognitive test , disease , test (biology) , dementia , psychiatry , magnetic resonance imaging , radiology , geometry , mathematics , paleontology , biology
The purpose of this study is to investigate differences in and correlations between cognitive abilities and brain volumes in healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) groups. The Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD‐K), which is used to diagnose AD, was used to measure the cognitive abilities of the study subjects, and the volumes of typical brain components related to AD diagnosis—cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM)—were acquired. Of the CERAD‐K subtests, the Boston Naming Test distinguished significantly among the HC, MCI, and AD groups. GM and WM volumes differed significantly among the three groups. There was a significant positive correlation between Boston Naming Test scores and GM and WM volumes. In conclusion, the Boston Naming Test and GM and WM brain volumes differentiated the three tested groups accurately, and there were strong correlations between Boston Naming Test scores and GM and WM volumes. These results will help to establish a test method that differentiates the three groups accurately and is economically feasible. Clin. Anat. 29:473–480, 2016. © 2016 Wiley Periodicals, Inc.