The Human Brain in 1492 Pieces: Structure, Vasculature, and Tracts by Wieslaw L. Nowinski, Beng Choon Chua, Guoyu Qian, Yevgen Marchenko, Fiftarina Puspitasari, Natalia G. Nowinska, and Michael V. Knopp

As a continuing student and instructor of neuroanatomy, I have been waiting for this software for a very long time. The Human Brain in 1492 Pieces is a beautifully rendered, easy to use tool for beginners and advanced students of human neuroanatomy. If you plan to use this atlas in the classroom, I highly recommend taking the time to read the Introduction. This section provides information concerning the design of the atlas as well as the imaging methods used. The atlas is based on imagery collected from a single specimen with 3 T and 7 T MR [MP-RAGE, two-dimensional (2D)/3D time of flight (TOF), susceptibility weighted imaging (SWI), spoiled gradient-echo (SPGR), diffusion tensor imaging (DTI)]. The imagery includes a color, 3D rendered surface of the brain including the underlying white matter, subcortical nuclei, blood vessels and fibers, and gray scale MR images. The inclusion of DTI is especially useful as there is no way to present this information in a typical 2D photographic atlas. Following a warning that this atlas is not a guide for neurosurgery, you begin by hitting ‘‘Start’’ on the home page. The brain including the vasculature appears. I recommend hitting the ‘‘Help’’ key. The help page lists the features of the menus and how to use the right and left clicks on the mouse to rotate or pan through the imagery and is worth a few minutes of your time. Four menus run along the upper left of the screen and control gross features of the software. These menus may be used to toggle on and off large areas of the brain, for example, the entire cortex or cerebellum on the right or left or both sides. The same applies to the arteries, veins, and tracts. The menus along the right side of the screen add a higher degree of control and allow the user to visualize individual structures, for example, under the heading of Brain, it is possible to select subcortical and further select/deselect the amygdala. Depending on the degree of detail desired, it is often easier to use the menu in the upper left to deselect an entire system and use the right side menus to add back the structure of interest. Using this scheme, I was able to isolate several different structures in the subcortical and white matter regions but was unable to bring up individual areas of the cortex. Individual gyri may be highlighted but it is not possible for a gyrus to ‘‘stand alone.’’ By isolating structures listed in the subcortical and white matter menus, it is possible to then toggle on and off the veins, arteries, and tracts. The result is a rotatable, 3D image of the structure of interest and the vasculature and fiber tracts in its immediate vicinity. Following the tracts is made easiest by toggling off then adding back tracts of interest. As with the tracts, the den-