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Phase Partitioning of Biomolecules: Solubilities of Amino Acids
Author(s) -
Chen ChauChyun,
Zhu Yizu,
Evans Lawrence B.
Publication year - 1989
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.5420050309
Subject(s) - biomolecule , amino acid , solubility , chemistry , aqueous solution , ionic strength , phase (matter) , solvent , organic chemistry , biochemistry
The representation of phase equilibrium for amino acids, peptides, and proteins in solution is an important problem in the design and optimization of downstream processes for recovery of the biomolecules. This paper presents a molecular thermodynamic framework [1, 2] for the representation of the solubilities of amino acids and small peptides. With this framework, satisfactory results have been obtained in representing and predicting the solubilities of amino acids and small peptides in aqueous solution as functions of temperature, ionic strength, dipolar species concentrations, solvent compositions, and pH.