Premium
Continuous Cell Debris Filtration Using A Magnetically Stabilized Fluidized Bed
Author(s) -
Terranova Brenda E.,
Burns Mark A.
Publication year - 1989
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.5420050307
Subject(s) - filtration (mathematics) , debris , fluidized bed , adsorption , chromatography , fluidization , chemistry , adhesion , chemical engineering , materials science , composite material , geology , statistics , oceanography , mathematics , organic chemistry , engineering
The magnetically stabilized fluidized bed (MSFB) is capable, unlike most column operations, of handling streams with suspended particles. The MSFB has the contacting properties of a packed bed and the fluidity of a fluidized bed. When cell debris is fed into the column, either filtration or passage of the debris can be obtained depending on the bed height, solids velocity, pH, and liquid composition. Removal rates from as high as 99% to as low as 5% have been observed. The controlling mechanism of filtration appears to be an electrostatic adsorption of the debris onto the surface of the support. Debris/debris adhesion also affects filtration.