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Endothelial Volume and the Hydraulic Conductivity of Microvessels During Altered Pressure States
Author(s) -
Easterbrook M. H.,
Gross J. F.,
Intaglietta M.
Publication year - 1989
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.5420050108
Subject(s) - hydrostatic pressure , hydraulic conductivity , radius , capillary action , microcirculation , osmotic pressure , volume (thermodynamics) , chemistry , perfusion , hydrostatic equilibrium , capillary pressure , biophysics , swelling , endothelial stem cell , osmosis , thermodynamics , materials science , membrane , medicine , biology , biochemistry , composite material , soil science , environmental science , physics , computer security , in vitro , computer science , quantum mechanics , soil water , organic chemistry , porous medium , porosity
Low perfusion states of the microcirculation are known to produce endothelial cell swelling. In our study, irreversible thermodynamic transport equations are used to model the exchange of fluid between endothelial cells and the blood and tissue compartments. Results indicate that changes in the capillary hydrostatic pressure result in negligible radius changes, due to the small contribution of this pressure to the total pressure when the osmotic pressures of all species present are taken into account. Alterations in osmotic pressure via adjustment of the NaCl concentration in the blood produce fast and substantial changes in radius and therefore hydraulic resistance.