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Chitosan‐Alginate Complex Coacervate Capsules: Effects of Calcium Chloride, Plasticizers, and Polyelectrolytes on Mechanical Stability
Author(s) -
Daly Mary M.,
Knorr Dietrich
Publication year - 1988
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.5420040205
Subject(s) - coacervate , chitosan , polyelectrolyte , capsule , plasticizer , chemical engineering , coating , membrane , materials science , calcium alginate , permeability (electromagnetism) , chemistry , calcium , polymer chemistry , composite material , chromatography , polymer , organic chemistry , biochemistry , botany , engineering , biology
A method has been developed to form capsules with liquid cores where permeability can be modified without sacrificing membrane strength. The capsule is formed by dropwise addition of a 3% chitosan (polycation) solution into a 0.75% alignate (polyanion) solution. The resultant capsule consists of a liquid chitosan core with a hard alginate coating. The addition of CaCl 2 to chitosan and glucose to alginate increased capsule strength. The membranes formed were strong enough to require up to 100 Newton during uniaxial compression to burst a 6.4 mm diameter capsule.