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Correlation of Aqueous Two‐Phase Partitioning of Proteins with Changes in Free Volume
Author(s) -
Grossman Paul D.,
Gainer John L.
Publication year - 1988
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.5420040103
Subject(s) - volume (thermodynamics) , phase (matter) , aqueous solution , chemistry , free water , chromatography , thermodynamics , organic chemistry , geology , physics , geotechnical engineering
Phase separation and protein partitioning in polymer‐salt aqueous two‐phase systems have been correlated with changes in free volume. Both solute partitioning and phase stability are proposed to be related to those changes in liquid structure that can be described by measurements of the free volume of the mixture upon phase splitting.