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On the Optimization of Process Chromatography of Proteins
Author(s) -
Janson JanChrister,
Hedman Per
Publication year - 1987
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.5420030103
Subject(s) - selectivity , process (computing) , chromatography , column (typography) , chemistry , process optimization , column chromatography , computer science , chemical engineering , organic chemistry , catalysis , engineering , operating system , telecommunications , frame (networking)
In process scale chromatography, the efficacy of the separation is dependent on column packing characteristics such as selectivity, efficiency, dynamic capacity and flow resistance, as well as on the column design and the optimization of the running conditions. In general, it is more profitable to increase the selectivity of the process rather than the efficiency.