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A Generalized Model for Swelling‐Controlled Release Systems
Author(s) -
Singh S. K.,
Fan L. T.
Publication year - 1986
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.5420020309
Subject(s) - swelling , biological system , chemistry , computer science , chemical engineering , materials science , composite material , biology , engineering
A generalized model has been developed for simultaneous transport of an active agent and an organic penetrant in a planar glassy polymer matrix. The active agent diffuses out of the matrix undergoing macromolecular chain relaxation and volume expansion due to absorption of the organic penetrant from the environment into the matrix. The swelling behavior of the polymer is characterized by a stress‐induced drift velocity term “v” corresponding to the so‐called case‐II velocity. The change of volume due to the relaxation phenomenon is assumed instantaneous. The model incorporates convective transport of the two species induced by volume expansion and by stress gradient. The proposed phenomenological model reduces to a number of special cases depending on polymer‐penetrant system behavior.