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Evaluation of Supercritical Fluid Extraction in the Pharmaceutical Industry
Author(s) -
Larson Karen A.,
King Michael L.
Publication year - 1986
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.5420020206
Subject(s) - supercritical fluid , supercritical fluid extraction , extraction (chemistry) , pharmaceutical industry , chromatography , biochemical engineering , process engineering , chemistry , computer science , microbiology and biotechnology , engineering , organic chemistry , biology
Various steroids precipitate from supercritical CO 2 as very small particles but still retain their crystallinity. This suggests that SCFE in this industry could beutilized as a size reduction method as an alternative to milling. The applicationof SCFE as a separation technique is demonstrated by the simultaneous extraction and reaction of mevinolin, a metabolite of the fungus Aspergillus terreus.