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Continuous Affinity Chromatography Using a Magnetically Stabilized Fluidized Bed
Author(s) -
Burns Mark A.,
Graves David J.
Publication year - 1985
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.5420010206
Subject(s) - fluidized bed , countercurrent exchange , mixing (physics) , work (physics) , chromatography , fluidization , materials science , mechanics , fluidized bed combustion , process engineering , chemistry , thermodynamics , physics , engineering , organic chemistry , quantum mechanics
A new processing tool, the magnetically stabilized fluidized bed, offers opportunities for efficient fluid‐solids contact. The bubbling and mixing normally seen in a fluidized bed are eliminated, and continuous countercurrent contact is possible. This technique is especially suitable for biochemical separations, where cellular debris would clog an ordinary fixed bed. Preliminary modeling and experimental work on such a system is discussed, along with details of a relatively simple experimental system.