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Bionanoconjugate‐based composites for decontamination of nerve agents
Author(s) -
Borkar Indrakant V.,
Dinu Cerasela Zoica,
Zhu Guangyu,
Kane Ravi S.,
Dordick Jonathan S.
Publication year - 2010
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.498
Subject(s) - human decontamination , nerve agent , chemical warfare agents , paraoxon , chemical warfare , chemical agents , leaching (pedology) , environmentally friendly , chemistry , materials science , pulp and paper industry , waste management , enzyme , organic chemistry , microbiology and biotechnology , environmental science , biochemical engineering , acetylcholinesterase , ecology , soil water , soil science , engineering , biology
We have developed enzyme‐based composites that rapidly and effectively detoxify simulants of V‐ and G‐type chemical warfare nerve agents. The approach was based on the efficient immobilization of organophosphorus hydrolase onto carbon nanotubes to form active and stable conjugates that were easily entrapped in commercially available paints. The resulting catalytic‐based composites showed no enzyme leaching and rendered >99% decontamination of 10 g/m 2 paraoxon, a simulant of the V‐type nerve agent, in 30 minutes and >95% decontamination of diisopropylfluorophosphate, a simulant of G‐type nerve agent, in 45 minutes. The formulations are expected to be environmentally friendly and to offer an easy to use, on demand, decontamination alternative to chemical approaches for sustainable material self‐decontamination. © 2010 American Institute of Chemical Engineers Biotechnol. Prog., 2010