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Recent advances of dendrimer in targeted delivery of drugs and genes to stem cells as cellular vehicles
Author(s) -
Pishavar Elham,
Oroojalian Fatemeh,
Salmasi Zahra,
Hashemi Ezzat,
Hashemi Maryam
Publication year - 2021
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.3174
Subject(s) - stem cell , dendrimer , regenerative medicine , gene delivery , drug delivery , drug discovery , genetic enhancement , transfection , drug , gene , computational biology , chemistry , biology , microbiology and biotechnology , pharmacology , nanotechnology , bioinformatics , materials science , biochemistry
Stem cells can be used to repair dysfunctional and injured (or cancerous) tissues by delivering therapeutics. However, in comparison with other cells, it is harder to transfect drugs or genes into stem cells. Dendrimers have been considered as efficient vectors to deliver both genes and drugs to stem cells due to their unique properties including adjustable molecular weight and size, low toxicity, high loading capacity, and having multiple peripheral chemical agents which can be functionalized to improve deliverance efficiency. In this review, we discuss dendrimer‐mediated drug and gene delivery to stem cells as cellular vehicles and the role of this strategy in treating a variety of disorders via regenerative medicine approaches.