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Optimization of integrated chromatography sequences for purification of biopharmaceuticals
Author(s) -
Löfgren Anton,
YamaneeNolin Mikael,
Tallvod Simon,
Fons Joaquín G.,
Andersson Niklas,
Nilsson Bernt
Publication year - 2019
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.2871
Subject(s) - downstream (manufacturing) , column (typography) , scheduling (production processes) , sequence (biology) , computer science , downstream processing , perspective (graphical) , chromatography , process engineering , biochemical engineering , chemistry , mathematical optimization , mathematics , engineering , artificial intelligence , operations management , telecommunications , frame (networking) , biochemistry
With continued development of integrated and continuous downstream purification processes, tuning and optimization become increasingly complicated with additional parameters and codependent variables over the sequence. This article offers a novel perspective of nonlinear optimization of integrated sequences with regard to individual column sizes, flow rates, and scheduling. The problem setup itself is a versatile tool to be used in downstream design which is demonstrated in two case studies: a four‐column integrated sequence and a continuously loaded twin‐capture setup with five columns.