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Effects of glucose and nitrogen source concentration on batch fermentation kinetics of Lactococcus lactis under hemin‐stimulated respirative condition
Author(s) -
Razvi Azher,
Zhang Zisheng,
Lan Christopher Q.
Publication year - 2008
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1002/btpr.16
Subject(s) - lactococcus lactis , chemistry , kinetics , hemin , substrate (aquarium) , fermentation , nitrogen , food science , biomass (ecology) , biochemistry , chromatography , nuclear chemistry , bacteria , biology , enzyme , lactic acid , organic chemistry , heme , ecology , genetics , physics , quantum mechanics , agronomy
Analytical solutions to the ordinary differential equations governing the kinetics of cell growth, substrate utilization, and product formation of batch fermentation processes were derived and used to study the kinetics of the hemin‐stimulated respiratory cultivation of Lactococcus lactis at varied initial glucose concentrations and nitrogen source concentrations. Studies revealed that initial glucose concentration varying in the range of 60 to 90 g/L had no significant substrate inhibitive effect. Furthermore, elevating the concentration of complex nitrogen sources while maintaining glucose concentration at 60% led to a high final biomass concentration of 6.6 g/L, substantially higher than that obtained with the basic medium, which was 4.1 g/L.