Open AccessA skin patch integrating swellable microneedles and electrochemical test strips for glucose and alcohol measurement in skin interstitial fluid
Author(s) -
Zheng Mengjia,
Zhang Yuyue,
Hu Tianli,
Xu Chenjie
Publication year - 2023
Publication title -
bioengineering and translational medicine
Language(s) - English
Resource type - Journals
ISSN - 2380-6761
DOI - 10.1002/btm2.10413
Subject(s) - materials science , interstitial fluid , strips , biomedical engineering , alcohol , composite material , nanotechnology , chemistry , medicine , organic chemistry , pathology
Microneedle (MN)‐based diagnostic devices can efficiently access skin interstitial fluid (ISF) for accurate and minimally invasive detection of health‐related biomarkers. This work reports a biomarker (i.e., glucose or alcohol) monitoring MN device that is composed of swellable MNs and electrochemical test strip. This device is constructed by adhering MN patch on the electrochemical strips using the chitosan as the connecting layer. The MNs penetrate the skin for extraction of ISF that flows to the backing layer of MNs and is analyzed by the test strip. In the in vitro skin models, this device accurately detects the glucose from 0 mM to 12 mM and alcohol from 0 mM to 20 mM. In vivo experiment shows this MN device is capable of minimally invasive sampling of ISF and analysis of glucose levels to determine the glycemic status of mice.