Open AccessThree‐dimensional morphological revealing of human placental villi with common obstetric complications via optical coherence tomography
Author(s) -
Ni Guangming,
Zhong Junming,
Gao Xuemei,
Wu Renxiong,
Wang Wenjing,
Wang Xiaoshan,
Xie Yao,
Liu Yong,
Mei Jie
Publication year - 2023
Publication title -
bioengineering and translational medicine
Language(s) - English
Resource type - Journals
ISSN - 2380-6761
DOI - 10.1002/btm2.10372
Subject(s) - optical coherence tomography , coherence (philosophical gambling strategy) , obstetrics , medicine , physics , radiology , quantum mechanics
Placental villi play a vital role in human fetal development, acting as the bridge of material exchange between the maternal and fetal. The abnormal morphology of placental villi is closely related to placental circulation disorder and pregnancy complications. Revealing placental villi three‐dimensional (3D) morphology of common obstetric complications and healthy pregnancies provides a new perspective for studying the role of the placenta and its villi in the development of pregnancy diseases. In this study, we established a noninvasive, high‐resolution 3D imaging platform via optical coherence tomography to reveal placental villi 3D morphological information of diseased and normal placentae. For the first time, 3D morphologies of placental villous tree structures in common obstetric complications were quantitatively revealed and corresponding 3D information could visualize the morphological characteristics of the placental villous tree from a more intuitive perspective, providing helpful information to the study of fetal development, feto‐maternal material exchange, and gestational complications treatment.