Open AccessIntradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
Author(s) -
Kuwentrai Chaiyaporn,
Yu Jinming,
Rong Li,
Zhang BaoZhong,
Hu YeFan,
Gong HuaRui,
Dou Ying,
Deng Jian,
Huang JianDong,
Xu Chenjie
Publication year - 2021
Publication title -
bioengineering and translational medicine
Language(s) - English
Resource type - Journals
ISSN - 2380-6761
DOI - 10.1002/btm2.10202
Subject(s) - spike protein , intradermal injection , receptor , protein subunit , coronavirus , covid-19 , immunology , respiratory system , medicine , virology , chemistry , biology , pathology , gene , biochemistry , anatomy , infectious disease (medical specialty) , disease
The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein contains an immunogenic receptor‐binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S‐RBD vaccine using a dissolvable microneedle skin patch can induce both significant B‐cell and significant T‐cell responses against S‐RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.