Open AccessNanocrystals: A perspective on translational research and clinical studies
Author(s) -
Jarvis Maria,
Krishnan Vinu,
Mitragotri Samir
Publication year - 2019
Publication title -
bioengineering and translational medicine
Language(s) - English
Resource type - Journals
ISSN - 2380-6761
DOI - 10.1002/btm2.10122
Subject(s) - nanocrystal , nanotechnology , translational research , bioavailability , drug delivery , translation (biology) , materials science , medicine , chemistry , pharmacology , biochemistry , pathology , messenger rna , gene
Poorly soluble small molecules typically pose translational hurdles owing to their low solubility, low bioavailability, and formulation challenges. Nanocrystallization is a versatile method for salvaging poorly soluble drugs with the added benefit of a carrier‐free delivery system. In this review, we provide a comprehensive analysis of nanocrystals with emphasis on their clinical translation. Additionally, the review sheds light on clinically approved nanocrystal drug products as well as those in development.