Open AccessEmerging applications of exosomes in cancer therapeutics and diagnostics
Author(s) -
Inamdar Sahil,
Nitiyanandan Rajeshwar,
Rege Kaushal
Publication year - 2017
Publication title -
bioengineering and translational medicine
Language(s) - English
Resource type - Journals
ISSN - 2380-6761
DOI - 10.1002/btm2.10059
Subject(s) - microvesicles , extracellular vesicles , exosome , nucleic acid , drug delivery , biomolecule , nanotechnology , biological fluids , computational biology , isolation (microbiology) , chemistry , biology , microrna , microbiology and biotechnology , bioinformatics , biochemistry , materials science , gene , chromatography
Exosomes are nanoscale extracellular vesicles that are shed from different cells in the body. Exosomes encapsulate several biomolecules including lipids, proteins, and nucleic acids, and can therefore play a key role in cellular communication. These vesicles can be isolated from different body fluids and their small sizes make them attractive in various biomedical applications. Here, we review state‐of‐the art approaches in exosome isolation and purification, and describe their potential use in cancer vaccines, drug delivery, and diagnostics.