Premium
Genetics and delusional disorder
Author(s) -
Cardno Alastair G.,
McGuffin Peter
Publication year - 2006
Publication title -
behavioral sciences and the law
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 74
eISSN - 1099-0798
pISSN - 0735-3936
DOI - 10.1002/bsl.681
Subject(s) - delusional disorder , schizophrenia (object oriented programming) , psychiatry , genetic association , psychology , delusion , medicine , schizoaffective disorder , linkage (software) , psychosis , clinical psychology , genetics , biology , genotype , gene , single nucleotide polymorphism
This article gives an overview of genetic research approaches and their application to delusional disorder. Most studies have been based on small samples and have had other methodological limitations, so it is not clear whether there is a genetic contribution to the aetiology of delusional disorder. It is unlikely that delusional disorder is strongly related genetically to affective disorder or schizophrenia, but more subtle relationships cannot be ruled out. The rarity of multiply affected families prohibits linkage studies and, to date, molecular genetic investigations have been mainly limited to small association studies of dopamine receptor polymorphisms. A range of considerably larger, epidemiologically rigorous studies is required, but the uncommonness and other features of the disorder put strong limitations on the prospects for ascertaining adequate samples. Copyright © 2006 John Wiley & Sons, Ltd.