Open AccessIdentification of aberrant circulating mi RNA s in Parkinson's disease plasma samples
Author(s) -
Chen Lei,
Yang Junxiu,
Lü Jinhui,
Cao Shanshan,
Zhao Qian,
Yu Zuoren
Publication year - 2018
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.941
Subject(s) - downregulation and upregulation , microrna , disease , receiver operating characteristic , medicine , parkinson's disease , biology , gene , genetics
Objective To detect the aberrant expression of circulating mi RNA s and explore the potential early diagnostic biomarkers in patients with Parkinson's disease ( PD ). Methods Plasma samples were collected from 25 treatment‐naïve PD ‐diagnosed patients and 25 healthy controls followed by a real‐time PCR ‐based mi RNA screening analysis of neuron disease‐related mi RNA s. Results A subset of mi RNA s with aberrant expression levels in the plasma of PD ‐diagnosed patients were identified including upregulation of miR‐27a and downregulation of let‐7a, let‐7f, miR‐142‐3p, and miR‐222 with the AUC values more than 0.8 derived from the receiver operating characteristic curves. Conclusions The high sensitivity and specificity of the circulating mi RNA s may enable early diagnosis of PD . The study provides a group of novel mi RNA candidates for detecting PD .