Open AccessAsymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold
Author(s) -
Krøigård Thomas,
Wirenfeldt Martin,
Svendsen Toke K.,
Sindrup Søren H.
Publication year - 2018
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.917
Subject(s) - asymptomatic , medicine , subclinical infection , nerve fiber , cold sensitivity , quantitative sensory testing , nerve conduction study , peripheral neuropathy , sensory nerve , thermoreceptor , hyperhidrosis , mononeuropathy , dermatology , nerve conduction , sensory system , surgery , pathology , anatomy , neuroscience , diabetes mellitus , biochemistry , chemistry , gene , mutant , endocrinology , receptor , biology
Background Cold‐induced peripheral neuropathy has been described in individuals exposed to severe cold resulting in pain, hypersensitivity to cold, hyperhidrosis, numbness, and skin changes. Nerve conduction studies and thermal detection thresholds are abnormal in symptomatic patients, and intraepidermal nerve fiber density ( IENFD ) in skin biopsies is reduced. Case presentation A 41‐year‐old male was included as a healthy subject in a study of the spontaneous variability of quantitative sensory testing ( QST ), nerve conduction studies ( NCS ), and IENFD . Unexpectedly, IENFD was significantly reduced, whereas the rest of the examination was normal except for reduced vibration detection threshold. The results were confirmed at follow‐up examination. The subject had been repeatedly exposed to severe cold resulting in short lasting numbness and paresthesia while living in the eastern part of Greenland and the northern part of Norway. Conclusion Loss of intraepidermal nerve fibers caused by exposure to severe cold may be asymptomatic, and their function assessed by thermal detection thresholds may be preserved. This case illustrates that QST and IENFD are complementary tests and that subclinical cold‐induced peripheral neuropathy may be prevalent in subjects living in or near polar regions which could have implications for the recruitment of healthy subjects.