Open AccessCortical morphology in patients with transient global amnesia
Author(s) -
Kim Hyung Chan,
Lee Byung In,
Kim Sung Eun,
Park Kang Min
Publication year - 2017
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.872
Subject(s) - transient global amnesia , brain morphometry , magnetic resonance imaging , lateralization of brain function , cortex (anatomy) , morphology (biology) , pathogenesis , medicine , amnesia , neuroimaging , pathology , radiology , psychology , neuroscience , biology , audiology , psychiatry , genetics
Objective This study evaluated alterations in cortical morphology in patients with transient global amnesia (TGA). Materials and Methods Diagnoses of TGA occurred at our hospital. Evaluation involved a structured interview to obtain clinical information and a brain magnetic resonance imaging scan. We analyzed whole‐brain T1‐weighted MRI data using FreeSurfer 5.1. Measures of cortical morphology, such as thickness, surface area, volume, and curvature were compared between patients with TGA and healthy controls. We also quantified the correlations between clinical variables and each measure of abnormal cortical morphology. Results Seventy patients met the inclusion criteria. Compared to healthy controls, patients with TGA had significant alterations in cortical thickness in several regions of bilateral hemisphere. Moreover, several regions of cortical volumes in left hemisphere were significantly different between patients with TGA and healthy controls. In addition, there were significant correlations between the durations of episodes and cortical thickness, especially in the parietal cortex. However, there were no differences between groups in other measures of cortical morphology, including surface area and curvatures. Conclusions We observed significant alterations in cortical morphology in patients with TGA; these alterations are implicated in the pathogenesis of TGA.