Open AccessLinking Y‐chromosomal short tandem repeat loci to human male impulsive aggression
Author(s) -
Yang Chun,
Ba Huajie,
Cao Yin,
Dong Guoying,
Zhang Shuyou,
Gao Zhiqin,
Zhao Hanqing,
Zhou Xianju
Publication year - 2017
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.855
Subject(s) - allele , haplotype , allele frequency , genetics , biology , microsatellite , medicine , gene
Men are more susceptible to impulsive behavior than women. Epidemiological studies revealed that the impulsive aggressive behavior is affected by genetic factors, and the male‐specific Y chromosome plays an important role in this behavior. In this study, we investigated the association between the impulsive aggressive behavior and Y‐chromosomal short tandem repeats (Y‐ STR s) loci. Methods The collected biologic samples from 271 offenders with impulsive aggressive behavior and 492 healthy individuals without impulsive aggressive behavior were amplified by PowerPlex R Y23 PCR System and the resultant products were separated by electrophoresis and further genotyped. Then, comparisons in allele and haplotype frequencies of the selected 22 Y‐ STR s were made in the two groups. Results Our results showed that there were significant differences in allele frequencies at DYS 448 and DYS 456 between offenders and controls ( p < .05). Univariate analysis further revealed significant frequency differences for alleles 18 and 22 at DYS 448 (0.18 vs 0.27, compared to the controls, p = .003, OR =0.57,95% CI =0.39–0.82; 0.03 vs 0.01, compared to the controls, p = .003, OR =7.45, 95% CI =1.57–35.35, respectively) and for allele 17 at DYS 456 (0.07 vs 0.14, compared to the controls, p = .006, OR =0.48, 95% CI =0.28–0.82) between two groups. Interestingly, the frequency of haploid haplotype 22‐15 on the DYS 448‐ DYS 456 ( DYS 448‐ DYS 456‐22‐15) was significantly higher in offenders than in controls (0.033 vs 0.004, compared to the control, p = .001, OR = 8.42, 95% CI =1.81–39.24). Moreover, there were no significant differences in allele frequencies of other Y‐ STR s loci between two groups. Furthermore, the unconditional logistic regression analysis confirmed that alleles 18 and 22 at DYS 448 and allele 17 at DYS 456 are associated with male impulsive aggression. However, the DYS 448‐ DYS 456‐22‐15 is less related to impulsive aggression. Conclusion Our results suggest a link between Y‐chromosomal allele types and male impulsive aggression.