Open AccessPlasma sphingolipids and depressive symptoms in coronary artery disease
Author(s) -
Dinoff Adam,
Saleem Mahwesh,
Herrmann Nathan,
Mielke Michelle M.,
Oh Paul I.,
Venkata Swarajya Lakshmi Vattem,
Haughey Norman J.,
Lanctôt Krista L.
Publication year - 2017
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.836
Subject(s) - sphingolipid , coronary artery disease , sphingomyelin , ceramide , medicine , depression (economics) , pathophysiology , endocrinology , chemistry , cholesterol , biochemistry , apoptosis , economics , macroeconomics
Abstract Background Depression is highly prevalent in individuals with coronary artery disease ( CAD ) and increases the risk of future cardiac events and mortality. Sphingolipids have been implicated in the pathophysiology of both CAD and depression. This study assessed the association between plasma sphingolipid concentrations and depressive symptoms in CAD subjects. Methods Depressive symptoms were measured using the depression subscale of the self‐reported Hospital Anxiety and Depression Scale ( HADS ). Sphingolipid concentrations were measured from fasting plasma samples using high‐performance liquid chromatography‐coupled electrospray ionization tandem mass spectrometry ( LC / MS / MS ). Linear regression models were used to assess associations between log‐transformed concentrations of plasma sphingolipids and depressive symptoms. Results A total of 111 CAD patients (mean ( SD ) age = 63.6 ± 6.4, 84.7% male) were included. In linear regression analyses, higher plasma concentrations of ceramides C16:0 (β = 0.204, p = .026) and C18:0 (β = 0.209, p = .023) and sphingomyelin SM 18:1 (β = 0.210, p = .024) were significantly associated with higher HADS depression subscale score after adjusting for covariates. Conclusion Sphingolipids, in particular the ceramide species C16:0 and C18:0 and the sphingomyelin species SM 18:1, may be implicated in the pathophysiology of depression in CAD . The association between plasma sphingolipid concentrations and depression should be further examined in CAD patients and in other populations.